2-Phenyl-2-(1-piperidinyl)propane
Product Specifications
UNSPSC Description
2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2-(1-piperidinyl)propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM)[1].
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-phenyl-2-1-piperidinyl-propane.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC(N1CCCCC1)(C2=CC=CC=C2)C
Molecular Weight
203.329
References & Citations
[1]Walsky RL, et al. A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos. 2007 Nov;35(11):2053-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W040468/2-Phenyl-2-1-piperidinyl-propane-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W040468/2-Phenyl-2-1-piperidinyl-propane-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
92321-29-4
Available Sizes
Curated Selection
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