2-Phenyl-2- (1-piperidinyl) propane
2-Phenyl-2- (1-piperidinyl) propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2- (1-piperidinyl) propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM) [1].
Product Specifications
CAS Number
[92321-29-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-phenyl-2-1-piperidinyl-propane.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(N1CCCCC1)(C2=CC=CC=C2)C
Molecular Formula
C14H21N
Molecular Weight
203.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Walsky RL, et al. A comparison of 2-phenyl-2- (1-piperidinyl) propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos. 2007 Nov;35 (11) :2053-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1; CYP2; CYP3
Available Sizes
Curated Selection
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