Hesperetin 7-O-glucoside

Hesperetin 7-O-glucoside is a typical flavonoid monoglucoside, which is an anti-inflammatory agent and an antihypertensive with orally active. Hesperetin 7-O-glucoside is a commonly used food adjuvant. Hesperetin 7-O-glucoside inhibits human intestinal maltase and human HMG-CoA reductase with Ki of 1.8 mM and 9.8 μM, respectively. Hesperetin 7-O-glucoside has antibacterial activity and can regulate intestinal flora and metabolic homeostasis in mice[1][2][3].

Product Specifications

CAS Number

[31712-49-9]

Product Name Alternative

Hes-7-G

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; HMG-CoA Reductase (HMGCR) ; Interleukin Related

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hesperetin-7-o-glucoside.html

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13

Molecular Formula

C22H24O11

Molecular Weight

464.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Young-Su Lee, et al. Enzymatic Bioconversion of Citrus Hesperidin by Aspergillus Sojae Naringinase: Enhanced Solubility of hesperetin-7-O-glucoside With in Vitro Inhibition of Human Intestinal Maltase, HMG-CoA Reductase, and Growth of Helicobacter Pylori. Food Chem. 2012 Dec 15;135 (4) :2253-9.|[2]Wu F, et al. In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity. J Agric Food Chem. 2021 Nov 3;69 (43) :12753-12762.|[3]Wu F, et al. Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. J Agric Food Chem. 2021 Feb 10;69 (5) :1478-1486.