UPSEM792
UPSEM792 is a pharmacologically selective effector molecules (PSEM) agonist for PSAM4-GlyR, with an affinity of Ki of 0.7 nM. uPSEM792 is a substrate for efflux transporters in brains of wild type and dual P-gp and BCRP knockout mice. uPSEM7952 is a possible lead for developing the PET radioligand for PSAM4-GlyR[1].
Product Specifications
CAS Number
2323525-19-3
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/upsem792.html
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CN1C2=C(C=C(C3CNCC4C3)C4=C2)N=CC1=O
Molecular Formula
C14H15N3O
Molecular Weight
241.29
References & Citations
[1]Nerella SG, et al., Synthesis and preclinical evaluation of [11C]uPSEM792 for PSAM4-GlyR based chemogenetics. Sci Rep. 2024 Jan 22;14 (1) :1886.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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