UPSEM792

UPSEM792 is a pharmacologically selective effector molecules (PSEM) agonist for PSAM4-GlyR, with an affinity of Ki of 0.7 nM. uPSEM792 is a substrate for efflux transporters in brains of wild type and dual P-gp and BCRP knockout mice. uPSEM7952 is a possible lead for developing the PET radioligand for PSAM4-GlyR[1].

Product Specifications

CAS Number

[2323525-19-3]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/upsem792.html

Purity

99.92

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CN1C2=C(C=C(C3CNCC4C3)C4=C2)N=CC1=O

Molecular Formula

C14H15N3O

Molecular Weight

241.29

References & Citations

[1]Nerella SG, et al., Synthesis and preclinical evaluation of [11C]uPSEM792 for PSAM4-GlyR based chemogenetics. Sci Rep. 2024 Jan 22;14 (1) :1886.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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