Coixol
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3].
Product Specifications
CAS Number
[532-91-2]
Product Name Alternative
6-Methoxy-2-benzoxazolinone; 6-MBOA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Natural Products
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Coixol.html
Purity
98.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OC2=CC(OC)=CC=C2N1
Molecular Formula
C8H7NO3
Molecular Weight
165.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Yusheng Hu, et al. Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells. Molecules|[2]Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86 (8) :1950-1959. |[3]Hameed A, et al. Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway. Eur J Pharmacol. 2019 Sep 5;858:172514.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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