Coixol

Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3].

Product Specifications

CAS Number

[532-91-2]

Product Name Alternative

6-Methoxy-2-benzoxazolinone; 6-MBOA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Coixol.html

Purity

98.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OC2=CC(OC)=CC=C2N1

Molecular Formula

C8H7NO3

Molecular Weight

165.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Yusheng Hu, et al. Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells. Molecules|[2]Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86 (8) :1950-1959. |[3]Hameed A, et al. Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway. Eur J Pharmacol. 2019 Sep 5;858:172514.