GPR61 Inverse agonist 1
GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM) . GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia[1].
Product Specifications
UNSPSC
12352005
Target
Orphan GPCR; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gpr61-inverse-agonist-1.html
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C(F)=CN=C1)CNC2=NC(OC)=C(C=C2)S(N(C3=NC(OCC)=CC(C)=N3)CCOC)(=O)=O
Molecular Formula
C22H26F2N6O5S
Molecular Weight
524.54
References & Citations
[1]Lees JA, et al. An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun. 2023 Sep 23;14 (1) :5938.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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