GPR61 Inverse agonist 1

GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM) . GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia[1].

Product Specifications

UNSPSC

12352005

Target

Orphan GPCR; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gpr61-inverse-agonist-1.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(C(F)=CN=C1)CNC2=NC(OC)=C(C=C2)S(N(C3=NC(OCC)=CC(C)=N3)CCOC)(=O)=O

Molecular Formula

C22H26F2N6O5S

Molecular Weight

524.54

References & Citations

[1]Lees JA, et al. An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun. 2023 Sep 23;14 (1) :5938.