Yohimbic acid (hydrate)

Yohimbic acid hydrate is an amphoteric demethylated derivative of Yohimbine (HY-12715) . Yohimbic acid hydrate exhibits vasodilatory action. Yohimbic acid hydrate also can be used for the research of osteoarthritis (OA) [1][2][3].

Product Specifications

CAS Number

[207801-27-2]

UNSPSC

12352005

Hazard Statement

H301-H311-H331

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/yohimbic-acid-hydrate.html

Purity

99.96

Solubility

DMSO : ≥ 125 mg/mL

Smiles

[H][C@]12C3=C(CCN1C[C@]4([H])CC[C@@H]([C@@H]([C@@]4([H])C2)C(O)=O)O)C(C=CC=C5)=C5N3.O

Molecular Formula

C20H26N2O4

Molecular Weight

358.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]HAMET R. Demonstration of the direct vasodilatory action of yohimbic acid and Py-tetrahydroquinoline. C R Hebd Seances Acad Sci. 1960 Jun 27;250:4473-5.|[2]HAMET R. Sympatholytic activity and toxicity of an amphoteric demethylated derivative of yohimbine: yohimbic acid. C R Hebd Seances Acad Sci. 1951 Oct 29;233 (18) :1069-71.|[3]Wang S, et, al. Significantly dysregulated genes in osteoarthritic labrum cells identified through gene expression profiling. Mol Med Rep. 2019 Aug; 20 (2) : 1716-1724.