Acetyl-L-carnitine

Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression[1][2][3].

Product Specifications

CAS Number

[3040-38-8]

Product Name Alternative

O-Acetyl-L-carnitine; ALCAR

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Apoptosis; Caspase

Type

Natural Products

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-Acetylcarnitine.html

Purity

99.90

Solubility

DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[N+](C)(C)C[C@H](OC(C)=O)CC([O-])=O

Molecular Formula

C9H17NO4

Molecular Weight

203.24

Precautions

H302, H312, H332

References & Citations

[1]Zhu X, et al. Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells. Arch Biochem Biophys. 2008 Oct 15;478 (2) :154-60.|[2]Wang SM, et al. A review of current evidence for acetyl-l-carnitine in the treatment of depression. J Psychiatr Res. 2014 Jun;53:30-7.|[3]Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42 (6) :1661-1675.