AZD 4017
AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC50 of 7 nM.
Product Specifications
CAS Number
1024033-43-9
UNSPSC
12352005
Hazard Statement
H302
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/AZD_4017.html
Purity
99.20
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)C[C@H]1CN(C2=NC(SCCC)=C(C(NC3CCCCC3)=O)C=C2)CCC1
Molecular Formula
C22H33N3O3S
Molecular Weight
419.58
Precautions
H302
References & Citations
[1]Scott JS, et al. Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[ (3S) -1-[5- (cyclohexylcarbamoyl) -6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017) . J Med Chem. 2012 Jun 28;55 (12) :5951-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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