IL-1R1, Mouse (HEK293, His)

IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM)[1]. IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway[4]. IL-1R1 Protein, Mouse (HEK293, His) is a recombinant mouse extracellular region of IL-1R1 (L20-K338) with a C terminal 6*His tag, which is produced in HEK293 cells.

LEIDVCTEYP NQIVLFLSVN EIDIRKCPLT PNKMHGDTII WYKNDSKTPI SADRDSRIHQ QNEHLWFVPA KVEDSGYYYC IVRNSTYCLK TKVTVTVLEN DPGLCYSTQA TFPQRLHIAG DGSLVCPYVS YFKDENNELP EVQWYKNCKP LLLDNVSFFG VKDKLLVRNV AEEHRGDYIC RMSYTFRGKQ YPVTRVIQFI TIDENKRDRP VILSPRNETI EADPGSMIQL ICNVTGQFSD LVYWKWNGSE IEWNDPFLAE DYQFVEHPST KRKYTLITTL NISEVKSQFY RYPFICVVKN TNIFESAHVQ LIYPVPDFK

[1]Diana Boraschi, et al. The family of the interleukin-1 receptors. Immunol Rev. 2018 Jan;281(1):197-232.|[2]Daniel P Nemeth, et al. Modulation of Neural Networks by Interleukin-1. Brain Plast. 2021 Aug 23;7(1):17-32.|[3]Naoe Kaneko, et al. The role of interleukin-1 in general pathology. Inflamm Regen. 2019 Jun 6;39:12.|[4]Yonggang Sha, et al. A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases. Self Nonself. 2011 Jan;2(1):35-42.|[5]Xiang Chu, et al. Coupling Between Interleukin-1R1 and Necrosome Complex Involves in Hemin-Induced Neuronal Necroptosis After Intracranial Hemorrhage. Stroke. 2018 Oct;49(10):2473-2482.|[6]Siri Tahtinen, et al. IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. Nat Immunol. 2022 Apr;23(4):532-542.