Amitifadine (hydrochloride)

Amitifadine (DOV-21947; EB-1010) hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

Product Specifications

CAS Number

[410074-74-7]

Product Name Alternative

DOV-21947 hydrochloride; EB-1010 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Amitifadine-hydrochloride.html

Purity

99.64

Solubility

DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

ClC(C=C1[C@]2(CNC3)[C@@H]3C2)=C(C=C1)Cl.[H]Cl

Molecular Formula

C11H12Cl3N

Molecular Weight

264.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37.|[2]Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461 (2-3) :99-104.