Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

H8-A5

H8-A5 is a novel human histone deacetylase 8 (HDAC8) inhibitor. A highly specific ZBG-based pharmacophore model was developed by incorporating a custom zinc-binding group (ZBG) feature. Pharmacophore-based virtual screening identified three novel HDAC8 inhibitors with low micromolar IC50 values (1.8-1.9 μM) . Further studies showed that H8-A5 was more selective for HDAC8 than HDAC1/4 and exhibited antiproliferative activity in MDA-MB-231 cancer cells. Molecular docking and molecular dynamics studies showed that H8-A5 could bind to HDAC8, providing a good starting point for the development of HDAC8 inhibitors for cancer treatment.

Product Specifications

CAS Number

[423731-10-6]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/h8-a5.html

Smiles

O=C(C(F)(F)F)C1=CC=C(CSC2=NC3=C(N2)C=CC=C3)O1

Molecular Formula

C14H9F3N2O2S

Molecular Weight

326.29

References & Citations

[1]Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Bovine Dehydroepiandrosterone Sulfate (DHEA-S) ELISA Kit-Competitive
EK1F633 96 Tests

Bovine Dehydroepiandrosterone Sulfate (DHEA-S) ELISA Kit-Competitive

Ask
View Details
Mouse Monoclonal Spike RBD Antibody (1042425) [PE]
FAB10827P 0.1 mL

Mouse Monoclonal Spike RBD Antibody (1042425) [PE]

Ask
View Details
Anti-NSE/ENO2 Antibody, Mouse Monoclonal
MBS8106846-01 0.1 mL

Anti-NSE/ENO2 Antibody, Mouse Monoclonal

Ask
View Details
Anti-NSE/ENO2 Antibody, Mouse Monoclonal
MBS8106846-02 5x 0.1 mL

Anti-NSE/ENO2 Antibody, Mouse Monoclonal

Ask
View Details
SOX10 Antibody
V2869-100UG 100 µg

SOX10 Antibody

Ask
View Details
TMEM115 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
46871061 1.0 µg DNA

TMEM115 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

Ask
View Details