Tripelennamine (hydrochloride)

Tripelennamine hydrochloride, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine hydrochloride lessens the allergic response of the organism caused by histamine. Tripelennamine hydrochloride can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].

Product Specifications

CAS Number

[154-69-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Tripelennamine-hydrochloride.html

Purity

99.81

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2.[H]Cl

Molecular Formula

C16H22ClN3

Molecular Weight

291.82

Precautions

H302, H315, H319, H335

References & Citations

[1]Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92 (4) :1515-23.|[2]Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23 (3) :145-52.|[3]Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39 (6) :669-76.