Ailanthone

Ailanthone (Δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM) .

Product Specifications

CAS Number

[981-15-7]

Product Name Alternative

Δ13-Dehydrochaparrinone

UNSPSC

12352005

Hazard Statement

H300

Target

Androgen Receptor

Type

Natural Products

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Ailanthone.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@@H]2O)[C@]([C@@]3([C@@H]4O)O)([H])[C@@]([C@](C5)([H])C4=C)(CO3)[C@@](OC5=O)([H])C[C@@]1([H])C(C)=CC2=O

Molecular Formula

C20H24O7

Molecular Weight

376.40

Precautions

H300

References & Citations

[1]He Y, et al. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun. 2016 Dec 13;7:13122.|[2]Zhuo Z, et al. Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo. Sci Rep. 2015 Nov 3;5:16185.