Naproxen (sodium)

Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.

Product Specifications

CAS Number

[26159-34-2]

UNSPSC

12352005

Hazard Statement

H302, H360

Target

Autophagy; COX

Type

Reference compound

Related Pathways

Autophagy; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Naproxen-sodium.html

Purity

99.74

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : 75 mg/mL (ultrasonic; warming)

Smiles

C[C@H](C(O[Na])=O)C1=CC2=CC=C(OC)C=C2C=C1

Molecular Formula

C14H13NaO3

Molecular Weight

252.24

Precautions

H302, H360

References & Citations

[1]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90 (24) :11693-7.|[2]Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351 (2) :308-16.|[3]Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.