GC7 Sulfate
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
Product Specifications
CAS Number
150417-90-6
UNSPSC
12352211
Hazard Statement
H314
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GC7_Sulfate.html
Concentration
10mM
Purity
98.0
Solubility
H2O : 3 mg/mL (ultrasonic; warming)
Smiles
NC(NCCCCCCCN)=N.O=S(O)(O)=O
Molecular Formula
C8H22N4O4S
Molecular Weight
270.35
Precautions
H314
References & Citations
[1]Bandino A, et al. Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients. Cell Oncol (Dordr) . 2014 Dec;37 (6) :387-98.|[2]Lou B, et al. N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells. Exp Cell Res. 2013 Oct 15;319 (17) :2708-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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