Prostaglandin F2α serinol amide

Prostaglandin F2α serinol amide is a serinolamide G protein-coupled receptor that increases calcium levels in human non-small cell lung cancer cells. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord[1][2][3].

Product Specifications

CAS Number

[1135226-99-1]

UNSPSC

12352211

Hazard Statement

H225, H319, H360

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/prostaglandin-f2α-serinol-amide.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCC(CO)NC(CCC/C=C\C[C@@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)CCCCC)=O

Molecular Formula

C23H41NO6

Molecular Weight

427.57

Precautions

H225, H319, H360

References & Citations

[1]Richie-Jannetta R, et al. Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells. Prostaglandins Other Lipid Mediat. 2010 Jun;92 (1-4) :19-24.|[2]McCracken J A, et al. Prostaglandin F2α identified as a luteolytic hormone in sheep[J]. Nature New Biology, 1972, 238 (83) : 129-134.|[3]Woodward DF, et al. Recent progress in prostaglandin F2α ethanolamide (prostamide F2α) research and therapeutics. Pharmacol Rev. 2013 Jul 26;65 (4) :1135-47.