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Sydowimide A

Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC50 values of 1.5, 2.4 and 18.83 μM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Phosphatase; SHP1

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sydowimide-a.html

Solubility

10 mM in DMSO

Smiles

COC(/C(N1C(CC(C1=O)C)=O)=C\NC2=CC=CC=C2)=O

Molecular Formula

C15H16N2O4

Molecular Weight

288.30

References & Citations

[1]Xuan Shi, et al. Chemical Epigenetic Regulation Secondary Metabolites Derived from Aspergillus sydowii DL1045 with Inhibitory Activities for Protein Tyrosine Phosphatases. Molecules. 2024 Jan 31;29 (3) :670.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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