Sydowimide A
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC50 values of 1.5, 2.4 and 18.83 μM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase; SHP1
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sydowimide-a.html
Solubility
10 mM in DMSO
Smiles
COC(/C(N1C(CC(C1=O)C)=O)=C\NC2=CC=CC=C2)=O
Molecular Formula
C15H16N2O4
Molecular Weight
288.30
References & Citations
[1]Xuan Shi, et al. Chemical Epigenetic Regulation Secondary Metabolites Derived from Aspergillus sydowii DL1045 with Inhibitory Activities for Protein Tyrosine Phosphatases. Molecules. 2024 Jan 31;29 (3) :670.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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