Physalin H

Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively[1].

Product Specifications

CAS Number

[70241-09-7]

UNSPSC

12352005

Target

Endogenous Metabolite; Hedgehog

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/physalin-h.html

Solubility

10 mM in DMSO

Smiles

C[C@@]([C@H](OC1=O)C2)(OC3=O)[C@](O[C@@]45C6=O)([C@]3(CC[C@@]([C@]([C@@]7(CC=C8)Cl)(C8=O)C)([H])[C@@]4([H])C[C@H]7O)O)[C@@]6([H])[C@]2([C@@]1([H])CO5)C

Molecular Formula

C28H31ClO10

Molecular Weight

562.99

References & Citations

[1]Arai MA, eta l. Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. Beilstein J Org Chem. 2014 Jan 13;10:134-40.