Physalin H
Product Specifications
UNSPSC Description
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively[1].
Target Antigen
Endogenous Metabolite; Hedgehog
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease;Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/physalin-h.html
Solubility
10 mM in DMSO
Smiles
C[C@@]([C@H](OC1=O)C2)(OC3=O)[C@](O[C@@]45C6=O)([C@]3(CC[C@@]([C@]([C@@]7(CC=C8)Cl)(C8=O)C)([H])[C@@]4([H])C[C@H]7O)O)[C@@]6([H])[C@]2([C@@]1([H])CO5)C
Molecular Weight
562.99
References & Citations
[1]Arai MA, eta l. Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. Beilstein J Org Chem. 2014 Jan 13;10:134-40.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N8270/Physalin-H-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N8270/
Clinical Information
No Development Reported
CAS Number
70241-09-7
Curated Selection
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