Zatebradine
Zatebradine (UL-FS-49 (free base) ; UL-FS-49CL (free base) ) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively[1].
Product Specifications
CAS Number
[85175-67-3]
Product Name Alternative
UL-FS-49 (free base) ; UL-FS-49CL (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HCN Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Zatebradine.html
Purity
99.27
Solubility
DMSO : ≥ 50 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=CC(OC)=C(OC)C=C3C1
Molecular Formula
C26H36N2O5
Molecular Weight
456.57
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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