Zatebradine

Zatebradine (UL-FS-49 (free base) ; UL-FS-49CL (free base) ) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively[1].

Product Specifications

CAS Number

[85175-67-3]

Product Name Alternative

UL-FS-49 (free base) ; UL-FS-49CL (free base)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCN Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Zatebradine.html

Purity

99.27

Solubility

DMSO : ≥ 50 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=CC(OC)=C(OC)C=C3C1

Molecular Formula

C26H36N2O5

Molecular Weight

456.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006 Apr;69 (4) :1328-37. Epub 2005 Dec 30.|[2]Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478 (2-3) :161-71.