10-Undecenoic acid (zinc salt)

10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[557-08-4]

Product Name Alternative

Zinc undecylenate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H410

Target

Amyloid-β; Bacterial; Fungal; Proteasome; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/10-Undecenoic-acid-zinc-salt.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=CCCCCCCCCC([O-])=O.C=CCCCCCCCCC([O-])=O.[Zn+2]

Molecular Formula

C22H38O4Zn

Molecular Weight

431.91

Precautions

H302, H315, H319, H410

References & Citations

[1]Brayden DJ, et al. Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative. AAPS J. 2014 Sep;16 (5) :1064-76.|[2]Day ZI, et al. Novel Formulation of Undecylenic Acid induces Tumor Cell Apoptosis. Int J Mol Sci. 2022 Nov 16;23 (22) :14170.|[3]Kim MH, et al. Stimulatory effect of undecylenic acid on mouse osteoblast differentiation. Phytother Res. 2010 Apr;24 (4) :559-64. |[4]Gonçalves LM, et al. Effects of undecylenic acid released from denture liner on Candida biofilms. J Dent Res. 2012 Oct;91 (10) :985-9.|[5]Lee E, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain. Eur J Pharm Sci. 2012 May 12;46 (1-2) :17-25.|[6]Jantas D, et al. An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. J Cell Biochem. 2015 Dec;116 (12) :2882-95. |[7]Fernandes S, et al. Curcumin and 10-Undecenoic acid zinc salt as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int. 2023 Mar;165:112519.|[8]Mayfosh A, et al. A Novel Ammonium Carboxylate Salt of Undecylenic Acid for the Topical Treatment of Gram-Positive and Antibiotic-Resistant Skin Infections. Exp Dermatol. 2025 Mar;34 (3) :e70075.