EZH2-IN-17
EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively) [1].
Product Specifications
CAS Number
2489672-09-3
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezh2-in-17.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CNC(C2=CC(C3=CC=C(C(N4CCOCC4)CC5)C5=C3)=CC(N(C6CCOCC6)CC)=C2C)=O)=C(C)C=C(C)N1
Molecular Formula
C36H46N4O4
Molecular Weight
598.77
References & Citations
[1]Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2) . Bioorg Med Chem Lett. 2023 Nov 11:129558.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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