Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Library Pack

Selection of Mouse Monoclonal antibodies specific to α-1-antichymotrypsin

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies: 13801 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-109.5 - Isotype IgG2a 13802 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-118.2 - Isotype IgG1 13803 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-128.1 - Isotype IgG1 13804 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-143.1 - Isotype IgG2a

Gene Name

SERPINA3

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=SERPINA3">SERPINA3</a>

UniProt

P01011

Cellular Locus

Secreted.

Host

Mouse

Reactivity

Human

Immunogen

Purified human serum alpha-1-antichymotrypsin.

Target Antigen

α-1-antichymotrypsin

Target

α-1-antichymotrypsin

Clonality

Monoclonal

Type

Antibody Library Pack

Applications

ELISA

Field of Research

Enzymes

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {PubMed:2404007}.

Additionnal Information

These antibodies have been qualified for use in ELISA to detect human a1AC. End users should determine optimal concentrations for their applications.

Storage Conditions

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

These antibodies specifically recognize human serum alpha-1-antichymotrypsin. They do not cross-react with alpha-1-antitrypsin.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Alpha 1-antichymotrypsin (alpha1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. alpha1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. This activity protects tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. alpha1AC is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. It is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils.