NS3861

NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1].

Product Specifications

CAS Number

[216853-59-7]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ns3861.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

BrC1=C(SC=C1)C2=CC(CCC3C2)N3C

Molecular Formula

C12H14BrNS

Molecular Weight

284.22

References & Citations

[1]Kasper Harpsøe, et al. Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J Biol Chem. 2013 Jan 25;288 (4) :2559-70.