Human CLEC4C Protein, Fc Tag
CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal (beta1-3/4) Glcc (beta1-2) Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
Product Specifications
UniProt
Q8WTT0
Expression Region
Asn 45 - Ile 213
Reactivity
Human
Conjugation
Unconjugated
Tag
N-Fc
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
95%
Form
Powder
Molecular Weight
46.4 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
NCBI Accession Number
Q8WTT0
Preservative
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
Available Sizes
Frequently Asked Questions
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