RafRBDGST (C-Raf)
Raf is a member of the serine/threonine proteine kinase family involved in regulation of cell growth and differentiation and is the most important effector of Ras. Full-length Raf is composed of three conserved regions responsible for interaction with Ras, for phos-phorylation and for catalytic activity. RafRBD (Ras binding domain, amino acids 50-132) mediates interaction with membrane-anchored Ras necessary for activation of the kinase activity of Raf. The GST-Tag facilitates the protein‘s application in typical GST pull-down assays. The protein is GST-tagged on its N-terminus. There is a 7 AA linker between GST and RBD.
Product Specifications
Product Name Alternative
Ras Binding Domain of Raf, C-Raf 1 Kinase, human, recombinant, E. coli
Source
E. coli
Origin
Human
Field of Research
Signal Transduction
Purity
> 90% (SDS-PAGE)
Form
Liquid (Supplied in PBS, pH 7.4)
Molecular Weight
Theoretical MW: 42 kDa
Storage Conditions
Store at -80 °C
Notes
For research use only.
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