H-Ras (G12V) GST
Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signaling and transport pathways. H-Ras is one of the classic human Ras proteins (H-, N-, K-Ras4A, and K-Ras4B) . The mutation G12V leads to elimination of the intrinsic GTPase activity. H-Ras (G12V) is effective in activation of PI3K and PKB, whereas N-Ras and K-Ras are more potent towards MAP kinase. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
Product Specifications
Product Name Alternative
Harvey rat sarcoma viral oncogene homolog, human, recombinant, E. coli
Source
E. coli
Origin
Human
Field of Research
Signal Transduction
Purity
> 90% (SDS-PAGE)
Form
Liquid (Supplied in 25 mM Tris-HCl pH 7.5, 150 mM NaCl, 5 mM MgCl 2and 5 mM beta-mercaptoethanol)
Storage Conditions
Store at -80 °C
Notes
For research use only.
Frequently Asked Questions
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