D-Thyroxine

D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. D-Thyroxine can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia[1][2][3].

Product Specifications

CAS Number

[51-49-0]

Product Name Alternative

D-T4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/d-thyroxine.html

Purity

98.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N[C@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(O)C(I)=C2)C(O)=O

Molecular Formula

C15H11I4NO4

Molecular Weight

776.87

Precautions

H302, H315, H319, H335

References & Citations

[1]Bantle JP, et, al. Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia. Am J Med. 1984 Sep;77 (3) :475-81. |[2]Gless KH, et, al. Influence of D-thyroxine on plasma thyroid hormone levels and TSH secretion. Horm Metab Res. 1977 Jan;9 (1) :69-73. |[3]TUCKER RG. The biologic effects of D-thyroxine. A review. Angiology. 1962 Feb;13:85-8.