Naphthoquine (phosphate)

Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine[1][2].

Product Specifications

CAS Number

[173531-58-3]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Naphthoquine-phosphate.html

Purity

99.59

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C(NC2=C(CCCC3)C3=C(O)C(CNC(C)(C)C)=C2)=CC=N4)C4=C1.O=P(O)(O)O.O=P(O)(O)O

Molecular Formula

C24H34ClN3O9P2

Molecular Weight

605.94

References & Citations

[1]Wang JY, et al.  Therapeutic efficacy of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Dec 30;26 (6) :442-4.|[2]Wang JY, et al. Naphthoquine phosphate and its combination with artemisinine. Acta Trop. 2004 Feb;89 (3) :375-81.