Human PCSK9 Protein, His Tag
Human PCSK9 (D374Y), His Tag is expressed from human 293 cells (HEK293) . It contains AA Gln 31 - Gln 692 (Accession # Q8NBP7-1 (D374Y) ) .
Product Specifications
UniProt
Q8NBP7
Expression Region
Gln 31 - Gln 692
Reactivity
Human
Conjugation
Unconjugated
Tag
C-6xHis
Field of Research
Metabolism Research
Endotoxin
1.0 EU per μg
Purity
90%
Form
Powder
Molecular Weight
13.8 kDa and 58.2 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculated MW of 13.8 kDa and 58.2 kDa respectively. The protein migrates as 15 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. The D374Y mutation results in higher affinity of PCSK9 for LDLR.
NCBI Accession Number
D374, Q8NBP7
Preservative
PBS, pH 7.4
Available Sizes
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