Lactacystin from Streptomyces spp.

<strong>Lactacystin from Streptomyces spp.</strong>_x000D_ <strong>Catalog number:</strong> B2010434_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 0.2 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 376.43_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> Highly pure Lactacystin from Streptomyces spp. This compound has antibiotic properties as well as proteasome inhibitory properties._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> Lactacystin_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Ōmura S, Crump A. Lactacystin: first-in-class proteasome inhibitor still_x000D_ excelling and an exemplar for future antibiotic research. J Antibiot (Tokyo)._x000D_ 2019 Apr;72(4):189-201._x000D_ _x000D_ 2: Simko F, Pechanova O, Repova K, Aziriova S, Krajcirovicova K, Celec P,_x000D_ Tothova L, Vrankova S, Balazova L, Zorad S, Adamcova M. Lactacystin-Induced_x000D_ Model of Hypertension in Rats: Effects of Melatonin and Captopril. Int J Mol_x000D_ Sci. 2017 Jul 25;18(8):1612._x000D_ _x000D_ 3: Tomoda H, Omura S. Lactacystin, a proteasome inhibitor: discovery and its_x000D_ application in cell biology. Yakugaku Zasshi. 2000 Oct;120(10):935-49._x000D_ _x000D_ 4: Fenteany G, Schreiber SL. Lactacystin, proteasome function, and cell fate. J_x000D_ Biol Chem. 1998 Apr 10;273(15):8545-8._x000D_ _x000D_ 5: Shibasaki M, Kanai M, Fukuda N. Total synthesis of lactacystin and_x000D_ salinosporamide A. Chem Asian J. 2007 Jan 8;2(1):20-38._x000D_ _x000D_ 6: Ito Y, Fukushima H, Katagiri T, Seo Y, Hirata S, Zhang M, Hosokawa R, Jimi E._x000D_ Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic_x000D_ differentiation by increasing active Smads. Biochem Biophys Res Commun. 2011 Apr_x000D_ 1;407(1):225-9._x000D_ _x000D_ 7: Legnani FG, Pradilla G, Thai QA, Fiorindi A, Recinos PF, Tyler BM, Gaini SM,_x000D_ DiMeco F, Brem H, Olivi A. Lacta_cystin exhibits potent anti-tumor activity in an_x000D_ animal model of malignant glioma when administered via controlled-release_x000D_ polymers. J Neurooncol. 2006 May;77(3):225-32._x000D_ _x000D_ 8: Perez-Alvarez S, Solesio ME, Manzanares J, Jordán J, Galindo MF. Lacta_cystin_x000D_ requires reactive oxygen species and Bax redistribution to induce mitochondria-_x000D_ mediated cell death. Br J Pharmacol. 2009 Oct;158(4):1121-30._x000D_ _x000D_ 9: Zhu W, Xie W, Pan T, Xu P, Fridkin M, Zheng H, Jankovic J, Youdim MB, Le W._x000D_ Prevention and restoration of lacta_cystin-induced nigrostriatal dopamine neuron_x000D_ degeneration by novel brain-permeable iron chelators. FASEB J. 2007_x000D_ Dec;21(14):3835-44._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/16941495/">10: Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N'Kuli F, Courtoy PJ,_x000D_ Octave JN. Lactacystin decreases amyloid-beta peptide production by inhibiting_x000D_ beta-secretase activity. J Neurosci Res. 2006 Nov 1;84(6):1311-22. </a>_x000D_ _x000D_ <strong>Products Related to Lactacystin from Streptomyces spp.</strong><a href="https://moleculardepot.com/product-category/Chemicals/">: Chemicals</a>