Anti-Mouse CD8a Antibody (53-6.7)

Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice[1][2][3].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

Transmembrane Glycoprotein

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-cd8a-antibody-53-6-7.html

Purity

95.00

Solubility

H2O

Smiles

[Anti-MouseCD8aAntibody(53-6.7)]

Molecular Weight

(154 kDa)

References & Citations

[1]Devine L, et al. Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Immunol Lett. 2004 May 15;93 (2-3) :123-30.|[2]Madi A, et al. CD8 agonism functionally activates memory T cells and enhances antitumor immunity. Int J Cancer. 2022 Sep 1;151 (5) :797-808.|[3]Uddin MN, et al. TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 2014 Feb 15;192 (4) :1946-53.