Merafloxacin
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].
Product Specifications
CAS Number
[91188-00-0]
Product Name Alternative
CI-934
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/merafloxacin.html
Purity
98.98
Solubility
DMSO : 5 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(CNCC)CC3)=C2F)C1=O)O
Molecular Formula
C19H23F2N3O3
Molecular Weight
379.40
Precautions
H302, H315, H319
References & Citations
[1]Sun Y, et, al. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv. 2020 Oct 21;2020.10.21.349225.|[2]Mandell W, et, al. In vitro activity of CI-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents. Antimicrob Agents Chemother. 1986 May;29 (5) :852-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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