Merafloxacin

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].

Product Specifications

CAS Number

[91188-00-0]

Product Name Alternative

CI-934

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/merafloxacin.html

Purity

98.98

Solubility

DMSO : 5 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(CNCC)CC3)=C2F)C1=O)O

Molecular Formula

C19H23F2N3O3

Molecular Weight

379.40

Precautions

H302, H315, H319

References & Citations

[1]Sun Y, et, al. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv. 2020 Oct 21;2020.10.21.349225.|[2]Mandell W, et, al. In vitro activity of CI-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents. Antimicrob Agents Chemother. 1986 May;29 (5) :852-7.