Allura Red AC

Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety[1][2][3].

Product Specifications

CAS Number

[25956-17-6]

Product Name Alternative

FD&C RED NO. 40; CI 16035

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; IFNAR; Interleukin Related; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Dye Reagents

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/allura-red-ac.html

Purity

99.00

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)(O[Na])=O)C=C3OC)=C(O)C=CC2=C1)(O[Na])=O

Molecular Formula

C18H14N2Na2O8S2

Molecular Weight

496.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Di Wu, et al. Characterisation of Interaction Between Food Colourant Allura Red AC and Human Serum Albumin: Multispectroscopic Analyses and Docking Simulations. Food Chem. 2015 Mar 1;170:423-9.|[2]Honma M. Evaluation of the in vivo genotoxicity of Allura Red AC (Food Red No. 40) . Food Chem Toxicol. 2015 Oct;84:270-5.|[3]Kwon YH, et al. Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nat Commun. 2022 Dec 20;13 (1) :7617.