Nicotianamine

Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC50 values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants[1][2].

Product Specifications

CAS Number

[34441-14-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Angiotensin-converting Enzyme (ACE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nicotianamine.html

Smiles

OC([C@@H](N)CCN[C@H](C(O)=O)CCN1[C@@H](CC1)C(O)=O)=O

Molecular Formula

C12H21N3O6

Molecular Weight

303.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bouazaoui M, et al. Synthesis and biological activity of nicotianamine and analogues. Adv Exp Med Biol. 2009;611:555-7. |[2]Takahashi S, et al. Nicotianamine is a novel angiotensin-converting enzyme 2 inhibitor in soybean. Biomed Res. 2015;36 (3) :219-24.