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HnNOS-IN-3

HnNOS-IN-3 (compound 39) is a selective nNOS inhibitor, with a Ki of 0.32 μM. The nNOS binding of hnNOS-IN-3 is competitive with L-arginine. The selectivity of hnNOS-IN-3 for nNOS versus iNOS (Ki=37 μM) and eNOS (Ki=9.4 μM) is 115-fold and 29-fold, respectively[1].

Product Specifications

CAS Number

163490-78-6

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hnnos-in-3.html

Solubility

10 mM in DMSO

Smiles

N=C(SCC)NC1=CC=C(C(F)(F)F)C=C1.[H]Cl

Molecular Formula

C10H12ClF3N2S

Molecular Weight

284.73

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shearer BG, et al. Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem. 1997 Jun 6;40 (12) :1901-5.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ENOS; iNOS; nNOS

Available Sizes

Frequently Asked Questions

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