Isocorynoxeine
Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM.
Product Specifications
CAS Number
51014-29-0
Product Name Alternative
7-Isocorynoxeine
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
5-HT Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Isocorynoxeine.html
Purity
99.52
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3
Molecular Formula
C22H26N2O4
Molecular Weight
382.45
Precautions
H301, H311, H331
References & Citations
[1]Matsumoto K, et al. Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies. Eur J Pharmacol. 2005 Jul 11;517 (3) :191-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin
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