(Rac) -MGV354
(Rac) -MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of [1].
Product Specifications
CAS Number
1852495-86-3
Product Name Alternative
CP 526555 (dihydrochloride)
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rac-mgv354.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N(C2=NC(C3=CC=CC4=C3C(NC5=CC=C(C6CCN(C(C7CC7)=O)CC6)C=C5C)CC4)=CC=C2)N=C1)O
Molecular Formula
C35H37N5O3
Molecular Weight
575.70
References & Citations
[1]Ehara T, et al. The Discovery of (S) -1- (6- (3- ((4- (1- (Cyclopropanecarbonyl) piperidin-4-yl) -2-methylphenyl) amino) -2,3-dihydro-1 H-inden-4-yl) pyridin-2-yl) -5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61 (6) :2552-2570.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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