(Rac) -MGV354

(Rac) -MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of [1].

Product Specifications

CAS Number

[1852495-86-3]

Product Name Alternative

CP 526555 (dihydrochloride)

UNSPSC

12352005

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rac-mgv354.html

Concentration

10mM

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)N(C2=NC(C3=CC=CC4=C3C(NC5=CC=C(C6CCN(C(C7CC7)=O)CC6)C=C5C)CC4)=CC=C2)N=C1)O

Molecular Formula

C35H37N5O3

Molecular Weight

575.70

References & Citations

[1]Ehara T, et al. The Discovery of (S) -1- (6- (3- ((4- (1- (Cyclopropanecarbonyl) piperidin-4-yl) -2-methylphenyl) amino) -2,3-dihydro-1 H-inden-4-yl) pyridin-2-yl) -5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61 (6) :2552-2570.