Recombinant Human Claudin-18.2 (CLDN18.2) -VLPs, Fluorescent (Active)
Product Specifications
CAS Number
9000-83-3
Gene Name
CLDN18.2-VLPs, Fluorescent
UniProt
P56856-2 (CLDN18.2)
Expression Region
1-261aa
Organism
Homo sapiens
Target Sequence
MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
Tag
C-terminal mCherry-tagged
Source
Mammalian cell
Field of Research
Signal Transduction
Assay Type
MP-VLP Transmembrane Protein & Active Protein & In Stock Protein
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Purity
The purity information is not available for VLPs proteins.
Activity
Yes
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 10 μg/mL can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 5.115-8.534 ng/mL.
The VLPs (CSB-MP3838) is negative control.
Length
Full Length of Isoform A2
Form
Lyophilized powder
Buffer
Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃.
Solubilize for 60 minutes at room temperature with occasional gentle miXIng. Avoid vigorous shaking or vorteXIng.
Molecular Weight
52.3 kDa
References & Citations
"Claudin-18 is an early-stage marker of pancreatic carcinogenesis."
Tanaka M., Shibahara J., Fukushima N., Shinozaki A., Umeda M., Ishikawa S., Kokudo N., Fukayama M.
J Histochem Cytochem 59:942-952 (2011)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Available Sizes
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