HSMG-1 inhibitor 11e
HSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM) [1].
Product Specifications
CAS Number
[1402452-10-1]
UNSPSC
12352005
Target
CDK; mTOR; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsmg-1-inhibitor-11e.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1C)(N(C)C)=O
Molecular Formula
C26H27N7O3S
Molecular Weight
517.60
References & Citations
[1]Ariamala Gopalsamy, et al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22 (21) :6636-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; mTOR; PI3Kα; PI3Kγ
Available Sizes
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