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(±) -Praeruptorin A

(±) -Praeruptorin A, a coumarin compound, is the main bioactive component in Peucedani Radix. As a calcium channel blocker, (±) -Praeruptorin A exhibits great antihypertensive effects. In addition, (±) -Praeruptorin A also has the effects of relaxing vascular smooth muscle, inhibiting airway inflammation and airway hyperresponsiveness. (±) -Praeruptorin A can be used for the research of allergic asthma, hypertension and other diseases[1][2][3].

Product Specifications

CAS Number

73069-25-7

UNSPSC

12352005

Target

Calcium Channel; Interleukin Related; NF-κB

Type

Natural Products

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/praeruptorin-a-1.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C=C(C)\C(O[C@H]1[C@@H](OC(C)=O)C2=C3C(C=CC(O3)=O)=CC=C2OC1(C)C)=O

Molecular Formula

C21H22O7

Molecular Weight

386.40

References & Citations

[1]Song YL, et al. Metabolic characterization of (±) -praeruptorin A in vitro and in vivo by high performance liquidchromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry. J Pharm Biomed Anal. 2014 Mar;90:98-110.|[2]Xu Z, et al. (+/-) -Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis. Chem Biol Interact. 2010 Jul 30;186 (2) :239-46.|[3]Xiong Y, et al. Effects of (±) -praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease. Eur J Pharmacol. 2012 May 15;683 (1-3) :316-24.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Calcium Channel; IL-13; IL-4; IL-5

Available Sizes

Frequently Asked Questions

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