L-741626
L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively[1].
Product Specifications
CAS Number
81226-60-0
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-741626.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1(C2=CC=C(Cl)C=C2)CCN(CC3=CNC4=C3C=CC=C4)CC1
Molecular Formula
C20H21ClN2O
Molecular Weight
340.85
References & Citations
[1]Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90 (3) :483-91.|[2]Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17 (3) :745-9.|[3]Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl) . 2009 Apr;203 (2) :317-27.|[4]Kulagowski JJ, et al. 3- ((4- (4-Chlorophenyl) piperazin-1-yl) -methyl) -1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39 (10) :1941-2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor
Available Sizes
Frequently Asked Questions
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