L-741626

L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively[1].

Product Specifications

CAS Number

[81226-60-0]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-741626.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1(C2=CC=C(Cl)C=C2)CCN(CC3=CNC4=C3C=CC=C4)CC1

Molecular Formula

C20H21ClN2O

Molecular Weight

340.85

References & Citations

[1]Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90 (3) :483-91.|[2]Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17 (3) :745-9.|[3]Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl) . 2009 Apr;203 (2) :317-27.|[4]Kulagowski JJ, et al. 3- ((4- (4-Chlorophenyl) piperazin-1-yl) -methyl) -1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39 (10) :1941-2.