Tiagabine

Tiagabine (NO050328) is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

Product Specifications

CAS Number

[115103-54-3]

Product Name Alternative

NO050328; NO328; TGB

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tiagabine.html

Purity

98.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1CN(CC/C=C(C2=C(C)C=CS2)/C3=C(C)C=CS3)CCC1)O

Molecular Formula

C20H25NO2S2

Molecular Weight

375.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Braestrup C, et al. (R) -N-[4,4-bis (3-methyl-2-thienyl) but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54 (2) :639-47.|[2]Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40 (3) : p. 32-40.|[3]Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50 (2) : p. 365-70.